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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K3
All Species:
13.64
Human Site:
S286
Identified Species:
25
UniProt:
P46734
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P46734
NP_002747.2
347
39318
S286
K
Q
V
V
E
E
P
S
P
Q
L
P
A
D
R
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
P322
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
V
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_546666
347
39324
S286
K
Q
V
V
E
E
P
S
P
Q
L
P
A
D
R
Cat
Felis silvestris
Mouse
Mus musculus
O09110
347
39278
S286
K
Q
V
V
E
E
P
S
P
Q
L
P
A
D
Q
Rat
Rattus norvegicus
Q4KSH7
419
47517
P340
T
K
V
L
Q
E
E
P
P
L
L
P
G
H
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511595
352
40240
S291
K
Q
V
V
E
E
P
S
P
Q
L
P
A
D
R
Chicken
Gallus gallus
Q90891
398
44059
P328
D
Y
I
V
N
E
P
P
P
K
L
P
N
G
V
Frog
Xenopus laevis
Q07192
446
50082
P372
T
Q
V
V
K
G
D
P
P
Q
L
S
N
S
E
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
E299
Q
Q
L
K
Q
V
V
E
E
P
S
P
Q
L
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477162
334
38176
G274
S
P
P
R
L
P
E
G
T
F
S
P
E
F
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
L290
V
S
G
D
P
P
I
L
H
P
D
S
D
D
F
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJV0
356
39818
P292
A
A
I
V
E
N
P
P
P
T
A
P
S
D
Q
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
P584
S
A
I
V
D
G
P
P
P
R
L
P
S
D
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
30.7
N.A.
99.1
N.A.
96.5
37.2
N.A.
89.7
30.3
42.1
75.3
N.A.
57
N.A.
37.7
N.A.
Protein Similarity:
100
47
N.A.
99.7
N.A.
98.8
56.7
N.A.
93.1
48.7
58
84.4
N.A.
72.9
N.A.
55.6
N.A.
P-Site Identity:
100
40
N.A.
100
N.A.
93.3
33.3
N.A.
100
40
40
13.3
N.A.
6.6
N.A.
6.6
N.A.
P-Site Similarity:
100
60
N.A.
100
N.A.
100
53.3
N.A.
100
53.3
46.6
33.3
N.A.
6.6
N.A.
6.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
33.7
23.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52.2
35.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
40
40
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
60
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
16
0
0
0
0
0
0
0
0
8
0
31
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
16
0
0
8
8
0
8
0
0
0
8
0
8
54
0
% D
% Glu:
0
0
0
0
39
54
16
8
8
0
0
0
8
0
16
% E
% Phe:
0
0
0
0
0
0
0
0
0
8
0
0
0
8
8
% F
% Gly:
0
0
8
0
0
16
0
8
0
0
0
0
8
16
0
% G
% His:
0
0
0
0
0
0
0
0
8
0
0
0
0
8
0
% H
% Ile:
0
0
31
0
0
0
8
0
0
0
0
0
0
0
0
% I
% Lys:
31
8
0
8
8
0
0
0
0
16
0
0
0
0
8
% K
% Leu:
0
0
8
8
8
0
0
8
0
8
70
0
0
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
0
0
16
8
0
0
0
0
0
0
16
0
0
% N
% Pro:
0
8
8
0
8
16
62
47
77
16
0
85
0
0
8
% P
% Gln:
8
47
0
0
16
0
0
0
0
39
0
0
8
0
16
% Q
% Arg:
0
0
0
8
0
0
0
0
0
8
0
0
0
0
24
% R
% Ser:
16
8
0
0
0
0
0
31
0
0
16
16
24
8
0
% S
% Thr:
16
0
0
0
0
0
0
0
8
8
0
0
0
0
0
% T
% Val:
8
0
47
70
0
8
8
0
0
0
0
0
0
0
16
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
16
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _